反应详情

Using an analogous procedure to that described in Example 1, 4-chloro-6-morpholinoquinazoline was reacted with 3-methylaniline to give 4-(3'-methylanilino)-6-morpholinoquinazoline hydrochloride in 76% yield, m.p. 276°-278° C. NMR Spectrum: (CD3SOCD3) 2.38 (s, 3H), 3.41 (m, 4H), 3.82 (m, 4H), 7.18 (d, 1H), 7.38 (m, 1H), 7.48 (s, 1H), 7.50 (d, 1H), 7.87 (s, 2H), 8.08 (s, 1H), 8.75 (s, 1H); Elemental Analysis: Found C, 63.9; H, 6.0; N, 15.4; C19H20N4O 1HCl requires C, 64.1; H, 5.9; N, 15.8%.