Acetic Acid → HCID 15296555, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.5 g (12.5 mmol) of 3-(2-cyanoethoxy)-2-(3-phenylpropyl)phenol (preceding example), 16 mL of 85% phosphoric acid, and 7.7 mL of acetic acid was stirred and heated at 125° C. for 23 hr. After being cooled, the mixture was diluted with water and worked-up with ethyl acetate in the usual manner giving 4 g of a red oil. This material was chromatographed on silica gel. Elution with hexane-ethyl acetate mixtures afforded 2.3 g (65.2%) of the title compound as a yellow solid.

Provenance & Evidence