HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-6-(tributylstannyl)pyridine → 1-(beta-D-glucopyranosyl)-4-chloro-3-(5-(6methoxy-2-pyridyl)-2-thienylmethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-6-(tributylstannyl)pyridine | HCID 10524891 | — |
| Reactant | 1-(4-ethylbenzyl)-5-bromopyridin-2(1H)-one | HCID 58242500 | — |
| Reactant | 1-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyl)-3-(5bromo-2-thienylmethyl)-4-chlorobenzene | HCID 60041289 | — |
| Product | 1-(beta-D-glucopyranosyl)-4-chloro-3-(5-(6methoxy-2-pyridyl)-2-thienylmethyl)benzene | HCID 66608917 | — |
Reaction Steps
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-(5-bromo-2-thienylmethyl)-4-chlorobenzene 71 obtained in Example 128-(4) and tri-n-butyl(6-methoxy-2-pyridyl)tin (see Gros, Philippe; Fort, Yves. Synthesis (1999), 754-756) were treated in a manner similar to Example 128-(5) and (6) to give the target compound. APCI-Mass m/Z 478/480 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202984B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-c5c29cb4aafc4d17b3cc895bef75ce21 |
| Source note | uspto-grants-2012_06 |