Cysteamine Hydrochloride → HCID 131718855, compound

HRID 2210205Notes

Reaction equation

HRID 2210205 reaction equation
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([Cl:6])=[O:5].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>CCOCC>[ClH:6].[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:14][CH2:13][CH2:12][NH2:11]

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Product 1

HCID 131718855HCID 131718855, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (2.5 g, 0.0158 mole) and 2-aminoethanethiol hydrochloride (1.14 g, 0.010 mole) is slowly heated to reflux for 15 min. The mixture is cooled to room temperature and treated with dry ether and filtered. The product is recrystallized from absolute ethanol to give 0.8 g of the title compound as a off-white solid, a 34% yield. m.p. 95°-115° C.

Workup

  1. temperatureis slowly heated
  2. temperatureto reflux for 15 min
  3. filtrationfiltered
  4. customThe product is recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-056fcc4e9a634e30919604b9511d3f19
Source dataset
uspto-grants-1995_10
Patent number
US05457134

Reaction notes

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