Ammonia → N-(3,4,4-trifluoro-3-butenyl)ethanediamide

HRID 2210207Notes

Reaction equation

HRID 2210207 reaction equation
O=[C:2]([NH:9][C:10](=[O:15])[C:11](OC)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[NH3:16]>CO>[F:8][C:4](=[C:5]([F:7])[F:6])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([NH2:16])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86748464Oxo[(3,4,4-trifluoro-3-butenyl)amino]oxoacetic acid, methyl ester

Product 1

HCID 15239196N-(3,4,4-trifluoro-3-butenyl)ethanediamideYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Compound 142 (5.0 g, 0.0237 mole) in methanol (50 mL) is saturated with dry gaseous ammonia at room temperature. The precipitate is filtered, washed with methanol and dried to give 3.16 g of the title compound as a white solid, a 68% yield. m.p. 190°-220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-8bf4a634614f4a62a3c2db13f17bdcdb
Source dataset
uspto-grants-1995_10
Patent number
US05457134

Reaction notes

Loading…