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温度

0 °C

2.5 g (0.0158 mole) 3,4,4-trifluoro-3-butenoyl chloride is added to a mixture of water (15 mL), dichloromethane (15 mL) and n-butyl amine (2.34 g, 0.032 mole) with stirring at 0° C. After stirring for 30 min, the organic layer is successively washed with 2N HCl, water, 5% sodium bicarbonate and brine, and dried. Evaporation of the solvent gave 2.85 g of title compound as a white solid, a 92% yield. m.p. 34°-36° C.

1. stirringAfter stirring for 30 min
2. washthe organic layer is successively washed with 2N HCl, water, 5% sodium bicarbonate and brine
3. customdried
4. customEvaporation of the solvent