2-Amino-1-butanol, (-)- → HCID 135767964, compound

Participants

Reaction Steps

0.98 g of (R)-2-amino-1-butanol and 1.78 g of 3-tertbutylsalicylaldehyde were disolved in 15 ml of methanol to prepare a methanol solution. The methanol solution was heated under reflux over 6 hours to obtain a reaction mixture. The solvent of the mixture was removed by distillation in vacuo to obtain a concentrated solution. The concentrated solution was placed on a silica gel column and eluted with a mixture of hexane and ethyl acetate (hexane:ethyl acetate=3:1) to give 2.04 g of (R)-2-[N-(3-tert-butylsalicylidene)amino]-1-butanol as yellow syrup (yield: 82%).

Provenance & Evidence