Ethyl chloroacetate → 2-(2-Methyl-thiazol-4-yl)morpholin-5-one

HRID 2210323Notes

Reaction equation

HRID 2210323 reaction equation
[OH:1][CH:2]([C:5]1[N:6]=[C:7]([CH3:10])[S:8][CH:9]=1)[CH2:3][NH2:4].Cl[CH2:12][C:13](OCC)=[O:14]>C(OCC)(=O)C.CO>[CH3:10][C:7]1[S:8][CH:9]=[C:5]([CH:2]2[O:1][CH2:12][C:13](=[O:14])[NH:4][CH2:3]2)[N:6]=1

Participants

4

Reactant 2

HCID 7751Ethyl chloroacetateHCID 167684962-Amino-1-(2-methyl-1,3-thiazol-4-yl)ethanol

Product 1

HCID 199743562-(2-Methyl-thiazol-4-yl)morpholin-5-one

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogously to Example S by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamine with ethyl chloroacetate and purification on a silica gel column using ethyl acetate/methanol =19:1 as eluant.

Sources & evidence

ORD record
ord-3a0a39d02cde481a81613fd31ec0e34b
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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