HCID 10978660, compound → N-[2-(4-methylaminocarbonylmethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

HRID 2210339Notes

Reaction equation

HRID 2210339 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.[CH3:14][NH:15][C:16]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([NH2:29])[CH3:28])=[CH:22][CH:21]=1)=[O:17]>>[CH3:14][NH:15][C:16]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([NH:29][CH2:9][CH:8]([OH:11])[C:6]2[N:7]=[C:3]([C:2]([F:13])([F:12])[F:1])[S:4][CH:5]=2)[CH3:28])=[CH:22][CH:21]=1)=[O:17]

Participants

3

Reactant 2

HCID 10978660HCID 10978660, compoundHCID 19974182HCID 19974182, compound

Product 1

HCID 19974232N-[2-(4-methylaminocarbonylmethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Procedure

Prepared analogously to Example 3 by reaction of 2-trifluoromethyl-4-bromoacetylthiazole and 2-(4-methylaminocarbonylmethoxyphenyl)-1-methylethylamine, followed by reduction and purification of the base on a silica gel column using methylene chloride/methanol =9:1 as eluant.

Workup

  1. customfollowed by reduction and purification of the base on a silica gel column

Sources & evidence

ORD record
ord-311ff5d3197d438cb12dfedc2736d665
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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