HCID 10978660, compound → HCID 19974254, compound

HRID 2210347Notes

Reaction equation

HRID 2210347 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.[CH3:14][NH:15][CH:16]([CH3:30])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:20][CH:19]=1>>[C:26]([CH2:25][O:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][CH:16]([N:15]([CH3:14])[CH2:9][CH:8]([OH:11])[C:6]2[N:7]=[C:3]([C:2]([F:13])([F:12])[F:1])[S:4][CH:5]=2)[CH3:30])=[CH:19][CH:20]=1)([O:28][CH3:29])=[O:27]

Participants

3

Reactant 2

HCID 10978660HCID 10978660, compoundHCID 19974331HCID 19974331, compound

Product 1

HCID 19974254HCID 19974254, compound

Procedure

Prepared analogously to Example 3 by reaction of 2-trifluoromethyl-4-bromoacetyl-thiazole and N-methyl-2-(4-carbomethoxymethoxyphenyl)-1-methylethylamine, followed by reduction and purification of the base on a silica gel column using ethyl acetate/methanol =40:1 as eluant.

Workup

  1. customfollowed by reduction and purification of the base on a silica gel column

Sources & evidence

ORD record
ord-fdb444eba35c42d69f411e26fe854efb
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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