HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- → N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- | HCID 14076239 | — |
| Reactant | 1-[4-(2-Carbomethoxy-1-methylethenyl)phenyl]propan-2-one | HCID 54548003 | — |
| Product | N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine | HCID 53895654 | — |
Reaction Steps
Prepared analogously to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-[4-(2-carbomethoxy-1-methylethenyl) phenyl]-propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/ methanolic ammonia =9.5/0.4/0.1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457205 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-025e19b02b174859ad1dcab581e20c36 |
| Source note | uspto-grants-1995_10 |