HCID 10978660, compound → HCID 19380209, compound

HRID 2210360Notes

Reaction equation

HRID 2210360 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.[C:14]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][NH2:28])=[CH:22][CH:21]=1)([O:16][CH3:17])=[O:15]>>[C:14]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][NH:28][CH2:9][CH:8]([OH:11])[C:6]2[N:7]=[C:3]([C:2]([F:13])([F:12])[F:1])[S:4][CH:5]=2)=[CH:22][CH:21]=1)([O:16][CH3:17])=[O:15]

Participants

3

Reactant 2

HCID 10978660HCID 10978660, compoundHCID 15674417HCID 15674417, compound

Product 1

HCID 19380209HCID 19380209, compound

Procedure

Prepared analogously to Example 3 by reaction of 2-trifluoromethyl-4-bromoacetyl-thiazole with 2-(4-carbomethoxymethoxyphenyl)ethanamine, followed by reduction.

Sources & evidence

ORD record
ord-6c9ac2d6e68e4cdda7bf20ef5b107937
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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