HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-oxo-, methyl ester → Methyl 3-[2-(4-hydroxyphenyl)-1-methylethyl]-5-(2-methyl-thiazol-4-yl)-2-oxazolidine carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-oxo-, methyl ester | HCID 70205 | — |
| Reactant | N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)ethanamine | HCID 19380198 | — |
| Product | Methyl 3-[2-(4-hydroxyphenyl)-1-methylethyl]-5-(2-methyl-thiazol-4-yl)-2-oxazolidine carboxylate | HCID 19974334 | — |
Reaction Steps
Prepared by analogy to Example 18 by reaction of N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)ethanamine with methyl glyoxylate, followed by purification of the base on a silica gel column using ether/petroleum ether =8:2 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457205 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-a807e4ef912e43e28bf714dd0ca92141 |
| Source note | uspto-grants-1995_10 |