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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2210375Generated: October 30, 2026

Chloroacetyl chloride → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)morpholin-5-one

https://huagongshe.com/reaction/2210375

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetyl chlorideHCID 6577—
ReactantSodium hydrideHCID 24758—
ReactantN-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamineHCID 14347763—
SolventToluene ethylacetateHCID 21584019—
ProductN-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)morpholin-5-oneHCID 19974202—

Reaction Steps

Prepared by analogy to Example 74a by reaction of N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine (diastereomer B), chloroacetyl chloride and sodium hydride, and purification of the base on a silica gel column using toluene/ethyl acetate =6:4 as eluant.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05457205
Source datasetuspto-grants-1995_10
ORD IDord-a57bca9e9f1f4d02b1773bf07970b14d
Source noteuspto-grants-1995_10