1-(4-(2-Hydroxyethoxy)phenyl)propan-2-one → N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)morpholine

HRID 2210384Notes

Reaction equation

HRID 2210384 reaction equation
O[C:2]1([C:8]2[N:9]=[C:10]([CH3:13])[S:11][CH:12]=2)[O:7][CH2:6][CH2:5][NH:4][CH2:3]1.[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](=O)[CH3:26])=[CH:20][CH:19]=1>>[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([N:4]2[CH2:5][CH2:6][O:7][CH:2]([C:8]3[N:9]=[C:10]([CH3:13])[S:11][CH:12]=3)[CH2:3]2)[CH3:26])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 145788571-(4-(2-Hydroxyethoxy)phenyl)propan-2-oneHCID 199742852-Hydroxy-2-(2-methyl-thiazol-4-yl)morpholine

Product 1

HCID 19974186N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)morpholine

Procedure

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)morpholine with 1-[4-(2-hydroxyethyoxy)phenyl]propan-2-one followed by purification on a silica gel column using methylene chloride as eluant.

Workup

  1. customfollowed by purification on a silica gel column

Sources & evidence

ORD record
ord-038d5c68197c4be2a49ecbddf58570d6
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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