Borane;tetrahydrofuran → HCID 19974145, compound

HRID 2210393Notes

Reaction equation

[C:1]([CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([NH:15][CH2:16][CH:17]([OH:24])[C:18]2[N:19]=[C:20]([Cl:23])[S:21][CH:22]=2)[CH3:14])=[CH:8][CH:7]=1)(O)=[O:2].B.O1CCCC1>>[OH:2][CH2:1][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([NH:15][CH2:16][CH:17]([OH:24])[C:18]2[N:19]=[C:20]([Cl:23])[S:21][CH:22]=2)[CH3:14])=[CH:8][CH:7]=1

Participants

Reactant 2

HCID 2723981Borane;tetrahydrofuran

HCID 19974292HCID 19974292, compound

Product 1

HCID 19974145HCID 19974145, compound

Procedure

Prepared by analogy to Example 71 by reaction of N-[2-(4-carboxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-chloro-thiazol-4-yl)ethanamine with borane/tetrahydrofuran complex (1 molar solution in tetrahydrofuran) for 24 hours.

Sources & evidence

ORD record: ord-69926803d3f042729f9573b3d8d29241
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05457205

Reaction notes

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