Potassium Bicarbonate → HCID 14347785, compound

HRID 2210399Notes

Reaction equation

HRID 2210399 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:16][CH2:17][CH:18]([OH:28])[C:19]2[N:20]=[C:21]([C:24]([F:27])([F:26])[F:25])[S:22][CH:23]=2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].[F:29][C:30]([F:41])([F:40])[C:31]1[S:32][CH:33]=[C:34]([C:36](=[O:39])[CH2:37]Br)[N:35]=1.C(=O)([O-])O.[K+]>CC(C)=O>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:17][CH:18]([C:19]3[N:20]=[C:21]([C:24]([F:26])([F:27])[F:25])[S:22][CH:23]=3)[O:28][C:36]([OH:39])([C:34]3[N:35]=[C:31]([C:30]([F:41])([F:40])[F:29])[S:32][CH:33]=3)[CH2:37]2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

5

Reactant 3

HCID 516893Potassium BicarbonateHCID 10978660HCID 10978660, compoundHCID 14347763N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Product 1

HCID 14347785HCID 14347785, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

from N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine (pair of diastereomers A) with 2-trifluoromethyl-4-bromoacetyl-thiazole and potassium hydrogen carbonate in acetone.

Sources & evidence

ORD record
ord-b70989b5557c4d95bb6f83dab16c0c93
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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