Isopropylamine → HCID 10632459, compound

HRID 2210419Notes

Reaction equation

HRID 2210419 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[CH:12]([NH2:15])([CH3:14])[CH3:13]>CO>[CH:12]([NH:15][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 1184264-Chloro-3-pyridinesulphonamide

Product 1

HCID 10632459HCID 10632459, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g of 4-chloropyridine-3-sulfonamide are dissolved in 50 cm3 of methanol and 50 cm3 of isopropylamine. The solution is introduced into a sealed tube and brought to 120° C. for 18 hours. After cooling, the reaction mixture is concentrated to dryness under vacuum (rotary evaporator) and the residue is taken up in 200 cm3 of water. The precipitate corresponding to the title compound is collected on a filter and washed with water. The precipitate is redissolved in 100 cm3 of dilute NaOH. The solution is decolored with charcoal, filtered and then acidified to a pH of 6.5-7. The crystalline precipitate obtained is collected on a filter, washed with water and dried.

Workup

  1. additionThe solution is introduced into a sealed tube
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture is concentrated to dryness under vacuum (rotary evaporator)
  4. customThe precipitate corresponding to the title compound is collected on
  5. filtrationa filter
  6. washwashed with water
  7. dissolutionThe precipitate is redissolved in 100 cm3 of dilute NaOH
  8. filtrationfiltered
  9. customThe crystalline precipitate obtained
  10. customis collected on a filter
  11. washwashed with water
  12. customdried

Sources & evidence

ORD record
ord-03077c71aeb0444c961291f34c0c064d
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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