2-Chloro-5-methyl-3-nitropyridine → HCID 19378730, compound

HRID 2210430Notes

Reaction equation

HRID 2210430 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([CH3:11])=[CH:4][N:3]=1.[NH2:12][C:13]([NH2:15])=[S:14]>C(O)C>[ClH:1].[CH3:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([S:14][C:13](=[NH:12])[NH2:15])=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 8183002-Chloro-5-methyl-3-nitropyridineHCID 2723790Thiourea

Product 1

HCID 19378730HCID 19378730, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 23 g of 2-chloro-5-methyl-3-nitropyridine and 11.14 g of thiourea in 130 cm3 of ethanol is brought to reflux for 2 hours. After cooling and addition of 20 cm3 of petroleum ether (40°-60° C.), the precipitate obtained is collected on a filter, washed with petroleum ether and dried.

Workup

  1. temperatureto reflux for 2 hours
  2. temperatureAfter cooling
  3. customthe precipitate obtained
  4. customis collected on a filter
  5. washwashed with petroleum ether
  6. customdried

Sources & evidence

ORD record
ord-ad0f54c7e37c4091bff2c78afa990aa7
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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