HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 3-methyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Aminopyridine-2-sulfonamide | HCID 14943702 | — |
| Catalyst | Ethyl Acetate | HCID 8857 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-methyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide | HCID 10679495 | — |
Reaction Steps
A mixture of 1 g of 3-aminopyridine-2-sulfonamide (Preparation 1) and 0.28 g of acetaldehyde in 10 cm3 of isopropanol to which 10 drops of ethyl acetate saturated with gaseous HCl have been added is brought to reflux for 1 to 2 hours. After cooling, a crystalline precipitate of the title compound is collected on a filter and washed with isopropanol. The 3-methyl-2,3-dihydro-4H-pyrido[3,2- e] [1,2,4]thiadiazine 1,1-dioxide is recrystallized from a CH3OH/H2O (1/4) mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05459138 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-fdcdcd1a12394d56a7e0a5572c0aa8fa |
| Source note | uspto-grants-1995_10 |