HCID 15651240, compound → HCID 178456991, compound

HRID 2210453Notes

Reaction equation

HRID 2210453 reaction equation
CS[C:3]1[NH:8][C:7]2[CH:9]=[CH:10][N:11]=[CH:12][C:6]=2[S:5](=[O:14])(=[O:13])[N:4]=1>C(N)(C)C>[CH:7]([NH:8][C:3]1[NH:8][C:7]2[CH:9]=[CH:10][N:11]=[CH:12][C:6]=2[S:5](=[O:14])(=[O:13])[N:4]=1)([CH3:9])[CH3:6]

Participants

3

Reactant 1

HCID 15651240HCID 15651240, compound

Product 1

HCID 178456991HCID 178456991, compound

Reagents, catalysts & solvents 1

HCID 6363IsopropylamineSolvent

Procedure

A solution of 0.7 g of 3-methylthio-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide obtained in Example 39 in 7 cm3 of isopropylamine is maintained in a sealed tube at 150° C. for 4 hours. After cooling, the solution is concentrated to dryness, the residue is taken up in 10 cm3 of water and the pH is adjusted to the value of 7. The precipitate obtained is collected on a filter, washed with water and recrystallized from hot water.

Workup

  1. temperatureAfter cooling
  2. concentrationthe solution is concentrated to dryness
  3. customThe precipitate obtained
  4. customis collected on a filter
  5. washwashed with water
  6. customrecrystallized from hot water

Sources & evidence

ORD record
ord-0a1c5dcb70934921885b59248b2a4019
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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