Cyclohexylamine → HCID 178527177, compound

Participants

Reaction Steps

A solution of 0.7 g of 3-methylthio-4H- pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide in 7 cm3 of cyclohexylamine is heated at reflux for 4 hours. The reaction mixture is concentrated under partial vacuum and the residue is taken up in 10 cm3 of water and is slightly basified by addition of 10% sodium hydroxide solution. The aqueous phase is stirred with 25 cm3 of diethyl ether in order to extract a possible excess of cyclohexylamine. After separation by settling, the aqueous solution is adjusted to a pH of 7 and the white precipitate is collected on a filter and washed with water. It is recrystallized from hot water.

Provenance & Evidence