Carbonic acid-guanidine (1:1) → HCID 11095586, compound

HRID 2210455Notes

Reaction equation

HRID 2210455 reaction equation
[NH2:1][C:2]1[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.C(=O)(O)O.[NH2:16][C:17](N)=N>O>[NH2:16][C:17]1[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[S:8](=[O:10])(=[O:9])[N:11]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 149437023-Aminopyridine-2-sulfonamide

Product 1

HCID 11095586HCID 11095586, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An intimate mixture of 1 g of 3-aminopyridine-2- sulfonamide (Preparation 1) and 2.1 g of guanidine carbonate is progressively brought to the molten state (200° C.) and then heated for 24 hours at this temperature. After cooling, the residue is taken up in water. The possible insoluble material is filtered and the filtrate, treated with animal charcoal, is acidified to a pH of 7. The white precipitate is collected on a filter, washed with water and recrystallized from hot water.

Workup

  1. customis progressively brought to the molten state (200° C.)
  2. temperatureheated for 24 hours at this temperature
  3. temperatureAfter cooling
  4. filtrationThe possible insoluble material is filtered
  5. additionthe filtrate, treated with animal charcoal
  6. customThe white precipitate is collected on a filter
  7. washwashed with water
  8. customrecrystallized from hot water

Sources & evidence

ORD record
ord-ea94e9904b3b42a880915f31b4e69d10
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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