Dicyclohexylcarbodiimide → HCID 86749041, compound

Participants

Reaction Steps

To a solution of 34.47 g of 3,4,5-trimethoxyphenylalanine methyl ester, 18.87 g of α-hydroxyiminoisocaproic acid, 14.96 g of N-hydroxysuccinimide in 1 liter of dioxane, was added 26.82 g of N,N'-dicyclohexylcarbodiimide, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was filtrated, and the filtrate was subjected to distillation to remove the solvent. The resulting residue was purified by means of a silica gel column chromatography (eluent: ethyl acetate:n-hexane=1:2) to obtain 42.70 g of N-(2-hydroxyimino-4-methylpentanoyl)-(3,4,5-trimethoxy)phenylalanine methyl ester.

Provenance & Evidence