Sodium Hydroxide → HCID 86749042, compound

Participants

Reaction Steps

To an ethanol solution (500 ml) of 31.98 g of N-(2-hydroxyimino-4-methylpentanoyl)-(3,4,5-trimethoxy)phenylalanine methyl ester was added 180 ml of 1N-sodium hydroxide aqueous solution, and the mixture was stirred at room temperature for 13 hours. After the removal of the solvent by distillation, the residue was acidified by adding with a hydrochloric acid, then was extracted with ethyl acetate. The ethyl acetate layer was washed with an aqueous solution saturated with sodium chloride and was dried with magnesium sulfate. By removal of the solvent by distillation, 30.93 g of N-(2-hydroxyimino-4-methylpentanoyl)-(3,4,5-trimethoxy)phenylalanine was obtained.

Provenance & Evidence