HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[7-(2-Chloro-4-methoxyphenoxy)octyl]imidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-4-methoxyphenol | HCID 87459 | — |
| Reactant | 1-(2-Iodooctyl)imidazole hydrochloride | HCID 18921813 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-[7-(2-Chloro-4-methoxyphenoxy)octyl]imidazole hydrochloride | HCID 18921882 | — |
Reaction Steps
Combine the product of step (b) (2.5 g) with 2-chloro-4-methoxyphenol (5.2 g) and potassium carbonate (10 g) in acetone (100 ml) and relux for 48 hours. Evaporate the solvent, extract the resultant residue with dichloromethane and purify on a silica gel column, eluting with 100% CH2Cl2 →10% CH3OH/CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05459144 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-323f6bc1d51c437786d02a9e00e42f84 |
| Source note | uspto-grants-1995_10 |