Lithium hydroxide, monohydrate → HCID 9955405, compound

Participants

Reaction Steps

A solution of 247 mg of lithium hydroxide monohydrate dissolved in 3 ml of water was added to a solution of 447 mg of ethyl 4-(1-hydroxy-1-methylethyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]-2-propylimidazole-5-carboxylate [prepared as described in step (a) above] dissolved in 5 ml of dioxane, and the resulting mixture was stirred at room temperature for 5 hours. At the end of this time, the dioxane in the reaction mixture was removed by evaporation under reduced pressure, and 5.9 ml of 1N aqueous hydrochloric acid were added to the residue. The crystals thus precipitated were collected by filtration and dried in air, to give 310 mg of the title compound, softening at 163° C. and melting at 183°-185° C.

Provenance & Evidence