Lithium hydroxide, monohydrate → HCID 15293906, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 279 mg of ethyl 4-isopropenyl-1-[(2'-methoxalylbiphenyl-4-yl)methyl)-2-propylimidazole-5-carboxylate [prepared as described in step (a) above] dissolved in 3 ml of dioxane was mixed with a solution of 123 mg of lithium hydroxide monohydrate dissolved in 3 ml of water, and the resulting mixture was stirred at 80° C. for 5 hours. At the end of this time, the dioxane was removed by distillation under reduced pressure, and 2.94 ml of 1N aqueous hydrochloric acid were added to the residual aqueous solution. The crystals which precipitated were collected by filtration, to give 214 mg of the title compound, melting at 150°-151° C.

Provenance & Evidence