Sodium Hydroxide → HCID 15293908, compound

Participants

Reaction Steps

4 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 170 mg of 4-(1-hydroxy-2-methylpropyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]-2-propylimidazole-5-carbonitrile [prepared as described in step (a) above] dissolved in 3 ml of hot ethanol, and the resulting mixture was stirred under reflux for 2.5 hours. At the end of this time, the ethanol was removed by evaporation under reduced pressure, and ethyl aceate was added to the residual aqueous solution. 4 ml of 1N aqueous hydrochloric acid were added to the mixture, after which the ethyl acetate layer was separated. This extract was then dried over anhydrous magnesium sulfate, and the solvent was removed by evaporation under reduced pressure to give 140 mg of the title compound as crystals, softening at 150° C., and melting at 165°-170° C. (with decomposition).

Provenance & Evidence