Sodium Hydroxide → HCID 15293909, compound

HRID 2210572Notes

Reaction equation

[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:33][CH2:34][CH3:35])[N:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([C:29]([O:31]C)=[O:30])=[O:28])=[CH:17][CH:16]=2)[C:11]=1[C:12]#[N:13])[C:3]([CH3:6])([CH3:5])[CH3:4].[OH-:36].[Na+]>>[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:33][CH2:34][CH3:35])[N:10]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([C:29]([OH:31])=[O:30])=[O:28])=[CH:19][CH:20]=2)[C:11]=1[C:12]([NH2:13])=[O:36])[C:3]([CH3:6])([CH3:4])[CH3:5]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19378980HCID 19378980, compound

Product 1

HCID 15293909HCID 15293909, compound

Procedure

246 mg of 4-(1-hydroxy-2,2-dimethylpropyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]-2-propylimidazole-5-carbonitrile [prepared as described in step (a) above] were subjected to hydrolysis using 6 ml of a 1N aqueous solution of sodium hydroxide in the same manner as described in Example 10(b), to give 182 mg of the title compound as crystals, melting at 198°-200° C.

Sources & evidence

ORD record: ord-6fe840bd21ee4b83917cd22bfd07fde8
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05459148

Reaction notes

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