Lithium hydroxide, monohydrate → HCID 19378943, compound

Participants

Reaction Steps

A solution of 81 mg of lithium hydroxide monohydrate dissolved in 5 ml of water was added to a solution of 380 mg of methyl 2-(N-t-butoxycarbonyl-N-methylaminomethyl)-4-(1-hydroxy-1-methylethyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]imidazole-5-carboxylate [prepared as described in step (a) above] dissolved in 5 mg of dioxane, and the resulting mixture was stirred at room temperature for 2.5 hours. At the end of this time, the dioxane was removed by distillation under reduced pressure, and then 1.93 ml of 1N aqueous hydrochloric acid was added to the residue. The material which precipitated was collected by filtration to give 339 mg of the title compound as an amorphous powder.

Provenance & Evidence