HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2210585Generated: November 1, 2026
Trimethylsilylacetylene → HCID 19379151, compound
https://huagongshe.com/reaction/2210585
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate | HCID 11036030 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 19379151 | HCID 19379151 | — |
Reaction Steps
To a solution of methyl 3-iodo-4-acetamido-5-chlorosalicylate (2 g) in distilled Et3N (60 ml) and dioxane (40 ml), trimethylsilylacetylene (1 ml), CuI (23 mg), and PdCl2 (PPh3)2 (152 mg) were added. The reaction mixture was stirred at 40° C. for 1.5 hours, after which time the solvents were removed in vacuo. A sample of the residue was purified by column chromatography for analytical purposes eluting with diethyl ether/hexane mixtures to yield the intermediate methyl 3-trimethylsilylethynyl-4-acetamido-5-chloro-salic ylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05459161 |
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| Source dataset | uspto-grants-1995_10 |
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| ORD ID | ord-80bef94b178c4672ba111c1bdedf94da |
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| Source note | uspto-grants-1995_10 |
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