HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzofurancarboxylic acid, 4-(acetylamino)-5-chloro-, methyl ester → Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzofurancarboxylic acid, 4-(acetylamino)-5-chloro-, methyl ester | HCID 11108337 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate | HCID 10635698 | 95.3% |
Reaction Steps
A solution of methyl-4-acetamido-5-chloro-benzo[b]furan-7-carboxylate (0.5 g) in acetone (300 ml) was stirred for 3 hours in presence of 5% Rh/C (0.5 g) in a hydrogen atmosphere. The catalyst was filtered off and the filtrate was evaporated in vacuo to yield 0.48 g of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05459161 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-a7a0ba52b95242adaba0cd2322430fe6 |
| Source note | uspto-grants-1995_10 |