Phenylacetylene → HCID 19379163, compound

HRID 2210587Notes

Reaction equation

HRID 2210587 reaction equation
I[C:2]1[C:11]([NH:12][C:13](=[O:15])[CH3:14])=[C:10]([Cl:16])[CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[C:3]=1[OH:17].[C:18]1([C:24]#[CH:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:13]([NH:12][C:11]1[C:2]2[CH:25]=[C:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:17][C:3]=2[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:9][C:10]=1[Cl:16])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 10821PhenylacetyleneHCID 11036030Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

Product 1

HCID 19379163HCID 19379163, compound

Procedure

Methyl 3-iodo-4-acetamido-5-chloro-salicylate was reacted with phenylacetylene in analogy to what described in Example 1, Method A and B, except that no SiO2 was added. After column chromatography the title product was obtained.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-7c6a3f73e54147bc852d37b7017a4ee0
Source dataset
uspto-grants-1995_10
Patent number
US05459161

Reaction notes

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