Ammonia → HCID 19379115, compound

Participants

Reaction Steps

The title compound was prepared by the procedure described in Example 37 using 3(-pyridin-3-yl)-7-[6-(4-fluorophenyl)indol-3-ylcarbonyl]-1H,3H-pyrrolo[1,2-c]thiazole, prepared as in Example 28, instead of 3-(Pyridin-3-yl)-7-(6-phenylmethoxyindol-3-yl)carbonyl-1H,3H-pyrrolo[1,2-c]thiazole. 1H NMR (DMSO-d6, 300 MHz) δ4.50 (d, 1H, J=15 Hz), 4.68 (dd, 1H, J=2, 15 Hz), 6.78 (d, 1H, J=3 Hz), 6.81 (s, 1H), 7.05 (d, 1H, J=3 Hz), 7.32 (t, 2H, J=9 Hz), 7.45 (dd, 1H, J=5, 8 Hz), 7.61 (dd, 1H, J=1, 9 Hz), 7.66-7.77 (m, 3H), 8.00 (bs, 2H), 8.30 (d, 1H, J=9 Hz), 8.53- 8.60 (m, 4H), MS (DCI/NH3) m/e 483 (M+H)+, 440. Anal calcd for C27H19FN4O2S: C, 67.21; H, 3.97; N, 11.61. Found: C, 66.92; H, 3.88; N, 11.44.

Provenance & Evidence