N-Methylethylamine → HCID 19379314, compound

HRID 2210636Notes

Reaction equation

HRID 2210636 reaction equation
[C:1]([O:7]C(C)(C)C)(=O)[CH2:2][C:3]([CH3:5])=[O:4].[CH2:12]([NH:14][CH3:15])[CH3:13]>C(O)(C)(C)C>[CH2:12]([N:14]([CH3:15])[C:1](=[O:7])[CH2:2][C:3]([CH3:5])=[O:4])[CH3:13]

Participants

4

Reactant 2

HCID 12219N-MethylethylamineHCID 15538Tert-butyl acetoacetate

Product 1

HCID 19379314HCID 19379314, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Conditions

Temperature
130 °C

Procedure

Into a 1 l stainless steel autoclave are introduced 158 g (1 mol) of tert-butyl acetoacetate and 61 g of N-ethyl-N-methylamine (1.05) mol), followed by heating at 130° C. for 6 hours; the pressure does not exceed 10 bars. The contents of the autoclave are transferred to a round-bottomed flask and the tert-butanol formed is evaporated under reduced pressure to give 140 g (98%) of N-ethyl-N-methylacetoacetamide which is sufficiently pure to be used in the following reaction.

Workup

  1. customThe contents of the autoclave are transferred to a round-bottomed flask
  2. customis evaporated under reduced pressure

Sources & evidence

ORD record
ord-ed06726612984c92b776a45f68df1b17
Source dataset
uspto-grants-1995_10
Patent number
US05459262

Reaction notes

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