Ethyl Acetate → HCID 44276728, compound

Participants

Reaction Steps

The title compound was prepared from (+)-cis-3-((3,5 -bis(trifluoromethyl)phenyl)methyloxy )-2-phenylpiperidine hydrochloride (Example 5) by isolation of the free base (by extraction into ethyl acetate from 10% Na2CO3 solution) and alkylation using a procedure analogous to that described in Example 3, m.p.=40°-42° C.: [α]26D =+149° (c=0.56, MeOH); Found: C, 59.97; H, 4.95; N, 3.36. C21H21NOF6.0.1(H2O) requires C, 60.17; H, 5.10; N, 3.34%.

Provenance & Evidence