Potassium Hydroxide → HCID 44307090, compound

Participants

Reaction Steps

The methyl ester (1.8 g; Example 8) was dissolved in tetrahydrofuran (25 ml) and a solution of potassium hydroxide (0.6 g) in water (25 ml) was added. The reaction mixture was heated at reflux for 18 H, then the organic layer was removed in vacuo and the aqueous layer removed by freeze-drying. The residue was dissolved in the minimum volume of water and the pH adjusted to 7.0 by the addition of 2M hydrochloric acid. The precipitated solid was isolated by filtration and washed with water and then recrystallised from ethanol, m.p.=60°-63° C. Found: C, 53.11; H, 4.54; N, 3.05. Calcd. for C22H21F6NO3.HCl C, 53.08; H, 4.45; N, 2.81%. m/z (CI+) 462 (MH).

Provenance & Evidence