Hydrochloric Acid → HCID 67751501, compound

Participants

Reaction Steps

The title compound was prepared from 1-t-butyloxycarbonyl-3-hydroxy-2-phenylpiperidine (Example 2c) and 3,5-dichlorobenzylbromide in an analogous manner to that described in Example 2d, e, m.p.=243°-245° C. 1H NMR (360 MHz, CDCl3) 1.49-1.53 (1H, m, CHH), 1.60-1.70 (1H, m, CHH), 1.82-1.95 (1H, m, CHH), 2.14-2.18 (1H, m, CHH), 2.79-2.87 (1H, m, NCHH), 3.27-3.31 (1H, m, NCHH), 3.60 (1H, s, OCHCHN), 3.82 (1H, s, OCHCHN), 4.02-4.05 (1H, d, J=13 Hz, OCHH), 4.31-4.35 (1H, d, J=13 Hz, OCHH), 6.80 (2H, s, ArH), 7.15 (1H, s, ArH), 7.25-7.35 (5H, m, ArH). Found: C, 58.24; H, 5.38; N, 3.91. Calcd. for C18H19NOCl2.HCl C, 58.01; H, 5.41; N, 3.76%.

Provenance & Evidence