HCID 86749053, compound → HCID 57010825, compound

Participants

Reaction Conditions

Reaction Steps

Sodium (5S,6S, 7S, 11R)-11-hydroxy-5-[(R)-1-hydroxyethyl]-4-oxo-8-oxa-3-azatricyclo[5.4.0.03,6 ]undec-1-ene -2-carboxylate ##STR54## (1) A solution of the compound obtained in Reference Example 29 (220 mg) in toluene (5 ml) was stirred at 50° C. for 4 hours and, then, at 80° C. for 8 hours. The solvent was then distilled off under reduced pressure and the residue was subjected to silica gel column chromatography (70-230 mesh, 20 g; ethyl acetate-hexane =1:2) to give allyl (5S,6S,7S,11R)-11-hydroxy-5-[(R) -1-hydroxyethyl]-4-oxo-8-oxa-3azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate (R2 =CH2CH=CH2) (93 mg).

Provenance & Evidence