Water → HCID 19377393, compound

Participants

Reaction Steps

A solution of 3-(2-fluoro-1-hydroxyethyl)-2-(phenylmethylthio)pyridine (16 g) in dry THF and acetic anhydride (7.4 g) is stirred with a catality amount of4-dimethylaminopyridine at room temperature for 12 hours. The reaction mixture is then poured into water and neutralized with dilute H2SO4. The mixture is extracted three times with methylene chloride, the combined extracts are dried (MgSO4), evaporated to obtain the desired product (oil, 17.2 g, Yield: 93%).

Provenance & Evidence