Boron tribromide → HCID 15293137, compound

Participants

Reaction Steps

To a stirred solution of boron tribromide (1.0M in methylene chloride, 7.2 mL) at 5° C. (ice water bath) was added under nitrogen the title compound of Example 16 (e) (1.0 g). The ice bath was removed, and the reaction was stirred at room temperature for 3 hours. The reaction was carefully quenched by the addition of 1NNaOH (10 mL), acidified by the addition of 1NHCl (15 mL), and evaporated under vacuum. The resulting solid was triturated with water, and the insoluble material was collected by filtration, washed three times with water, and then with ethyl ether. Crystallization from ethanol (3A) yielded the title compound as white crystals. Mp: 191°-194° C.

Provenance & Evidence