Benzoyl Peroxide → Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

Participants

Reaction Steps

2.3 g of methyl 4'-methyl-(1, 1'-biphenyl)-2-carboxylate was dissolved in 900 ml of tetrachloromethane under a nitrogen flow. Then there were added 17.8 g of 1-bromo-2,5-pyrrolidinedione and a catalytic amount of dibenzoyl peroxide. After stirring for 2.5 hours at reflux temperature under a nitrogen atmosphere, the reaction mixture was cooled and filtered. The flitrate was evaporated, yielding >30 g (100% ) of methyl 4'-(bromomethyl)[1,1'-biphenyl]-2-carboxylate as a crude residue (interm. 36).

Provenance & Evidence