4-Fluorobenzyl chloride → 1-(4-Fluorobenzyl)-2-chlorobenzimidazole

Participants

Reaction Conditions

Reaction Steps

11 g 2-chlorobenzimidazole are dissolved in 74 ml water and 17.35 ml 30% sodium hydroxide. The mixture is heated to 82° C. and to this they are slowly added 23.76 g 4-fluorobenzyl chloride within 5 hours. When the reaction is achieved, the solution is cooled to 20° C. and extracted with methylene chloride. The compound is recrystallized from ethyl acetate.

Provenance & Evidence