2-Methylbenzenesulfonic acid → HCID 19377751, compound

Participants

Reaction Steps

In 8.7 ml dihydropyran they are added 10 mg p.toluene sulphonic acid (APTS). To this mixture they are added within 30 mn at 60°, 20 g 1-chloro (4-tertbutylphenyl) butanol. After this addition the mixture is still heated at between 60° and 65° C. for 30 mn and kept under stirring for further 90 mn. 0.5 g sodium bicarbonate is thereafter added. The mixture is then stirred for 1 hour. The tetrahydropyranylated derivative is directly used without any further purification.

Provenance & Evidence