5-Bromo-2-chlorobenzaldehyde → 5-Bromo-2-chloro-1-(7-methoxybenzo[b]thiophen-2-ylmethyl)benzene

HRID 221085Notes

Reaction equation

HRID 221085 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:20]=1)[CH:18]=O>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH2:18][C:10]2[S:9][C:8]3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=3[CH:11]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 106089255-Bromo-2-chlorobenzaldehydeHCID 110842177-Methoxybenzo[b]thiophene

Product 1

HCID 666082925-Bromo-2-chloro-1-(7-methoxybenzo[b]thiophen-2-ylmethyl)benzene

Procedure

7-Methoxybenzo[b]thiophene (see WO 02/094262) and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 9 to give the target compound. APCI-Mass m/Z 367/369 (M+H).

Workup

  1. additionwere treated in a manner similar to Reference Example 9
  2. customto give the target compound

Sources & evidence

ORD record
ord-3bb990d183e645858349da709e597681
Source dataset
uspto-grants-2012_06
Patent number
US08202984B2

Reaction notes

Loading…