反应详情

Propionyl chloride (2.8 g, 29 mmol) was added to a mixture of 15 (1.2 g, 6.4 mmol) in CH2Cl2 and 5% aqueous NaOH. The mixture was stirred for 30 min and separated. The organic layer was extracted with water, separated and dried (MgSO4). The crude product was chromatographed (SiO2) with light petroleum-ether (2:1) as eluant yielding 0.98 g (62%) of 3-(N-propionyl-N-n-propylamino)chroman (16).

1. customseparated
2. extractionThe organic layer was extracted with water
3. customseparated
4. dry with materialdried (MgSO4)
5. customThe crude product was chromatographed (SiO2) with light petroleum-ether (2:1) as eluant