Benzoyl chloride → 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene

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Reaction Steps

To a solution of 53 g (0.23 mol) 8-chloro-2-(n-propyl)amino-l,2,3,4-tetrahydronaphthalene and 50 ml triethylamine in 500 ml dichloromethane was added dropwise 33 ml (40 g, 0.28 mol) benzoylchloride. After stirring over night at room temperature, 10% sodium carbonate was added and the mixture was shaken and separated. The organic phase was dried (magnesium sulphate), filtered and evaporated yielding 72 g (95%) raw product.

Provenance & Evidence