Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hex-5-en-3-ol | HCID 136489 | — |
| Reactant | Ethyl 2-chloro-2-(hydroxyimino)acetate | HCID 6399471 | — |
| Product | HCID 19606158 | HCID 19606158 | — |
Reaction Steps
To a solution of 6 g of 3-hydroxy-5-hexene in 150 ml of diethyl ether was added 18.1 g of ethyl chlorooximidoacetate. The solution was cooled to 0° C., and a solution of 21 ml of triethylamine in 210 ml of diethyl ether was added over 2.5 h. The amine hydrochloride salt was filtered and the residue was purified by silica gel column chromatography (5% to 10% EtOAc in CH2Cl2) to provide 5.5 g of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05461067 |
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| Source dataset | uspto-grants-1995_10 |
|---|
| ORD ID | ord-08bb95f6ba654972b867e46766492a13 |
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| Source note | uspto-grants-1995_10 |
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