HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(1-Pyrrolidinyl)-4-(hydroxymethyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl 2-(pyrrolidin-1-yl)thiazole-4-carboxylate | HCID 13339674 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(1-Pyrrolidinyl)-4-(hydroxymethyl)thiazole | HCID 18759150 | 4% |
Reaction Steps
Using the procedure of Example 23C but replacing ethyl 2-(4-morpholinyl)thiazole-4-carboxylate with ethyl 2-(1-pyrrolidinyl)thiazole-4-carboxylate provided, after silica gel chromatography using 2-4% methanol in chloroform, the desired compound (Rf 0.26, 4% methanol in chloroform) in 53% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05461067 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-91266432754f44158e42bf8245c09e20 |
| Source note | uspto-grants-1995_10 |